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Avodart is an androgen hormone inhibitor used in men to treat benign prostatic hyperplasia (BPH), which is swelling of the prostate. This medicine works by lowering the amount of the hormone responsible for prostate growth.

Avodart reduces urinary blockage and improves urine flow. This medicine should not be used in women and children.

Avodart works by inhibiting the action of a compound in the body called 5-alpha reductase. Avodart (Dutasteride) is called an enzyme, and is responsible for converting the male hormone testosterone into dihydrotestosterone (DHT), which is a more active form of testosterone.

The enlargement of the prostate gland, (known medically as benign prostatic hyperplasia), which often occurs in men with advancing age, is dependant upon testosterone being converted to DHT within the prostate gland. In the absence of DHT the prostate gland shrinks. By decreasing the amount of testosterone that is converted into DHT, dutasteride therefore helps to shrink the prostate gland.

The prostate gland is found only in men and lies at the top of the tube connecting the bladder to the outside (urethra). Enlargement of the prostate causes it to press on the urethra and bladder and can cause urinary symptoms such as difficulty passing urine and increased need to urinate, particularly at night. By shrinking the prostate, dutasteride relieves the pressure on the bladder and urethra. This allows urine to flow freely past the prostate and relieves the urinary symptoms associated with this condition.

Avodart is used to relieve moderate to severe symptoms of BPH and to reduce the risk of developing a complete inability to pass urine (acute urinary retention) that may require surgery.


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